I like the concept, but there so many things here that could be better.
I think the damage system is too punishing. If you get hit twice at the start of the game, you're dead. Depending on where items and enemies spawn, you could get killed before you even find a weapon. Yes, you always have your fist as a weapon, but it sucks. Not to mention that with the map being pretty much broken after floor one makes those chances that much more likely.
Following up on my last sentence, the map is broken after the first floor. There's no enemy indication and the yellow dot for the door location doesn't show up until you get really close to it.
Finally, the combat mechanics. It seems like enemies have better range for hitting you than you have for hitting them, unless you have the spray or fire extinguisher. I've tried to keep my distance so many times, I go for a hit with a cactus or a chair or whatever and they still hit me first, taking away most of my life points. IN JUST ONE HIT. Like I said earlier, I think the damage system is too punishing. It would be nice if I could take more than one hit without almost dying when I just started the game. It makes it difficult to level up, so I can actually take more damage.